Free gastroenterology powerpoint template free medical. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Powerpoint presentation the human digestive system. Pkadme in drug discovery oioverview pharmacokinetics, absorption, distribution, metabolism, elimination pharmacodynamics why these are important in early research, target validation and discovery programs when should they be determined early in the process examples. Gastrulation rearranges the blastula to form a threelayered embryo with a primitive gut. Gastroplus is a stateoftheart database and simulation computer program that contains the following elements.
Gastroenterology powerpoint template, backgrounds 02075. A framework for 2stage global sensitivity analysis of gastroplus. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda. The coefficient of variation for the intraday and interday run were. Small amount of precipitation but redissolution is fast. Gastroplus pbpk and admet predictor qsar modeling to prioritize testing of chemicals for the tox21 program presented work at past two society of toxicology sot meetings first publications expected in. Physiologically based pharmacokinetic modelling wikipedia. Shafer sl, varvel jr 1991 pharmacokinetics, pharmacodynamics, and rational opioid selection. Evaluation of the gastrointestinal tract authorstream. If this is the case it is usually found in the full download archive itself. To create more accurate search results for gastroplus try to exclude using commonly used keywords such as.
Free gastrointestinal powerpoint template download free. In vitroin vivo correlation for gliclazide immediaterelease. Ppt diabetic gastroparesis powerpoint presentation. Translating the effect of product manufacturing variants from.
Digestive system powerpoint lecture free download as powerpoint presentation. The upper gi tract esophagus stomach pancreas gallbladder liver 4. This case is composed of five processes such as 1 simulation, 2 verification, 3 understanding of parameter sensitivity, 4 optimization of the parameter and 5 final evaluation. Dissolution research a predictive tool for conventional and novel dosage forms.
Introduction to gastroplus mechanistic absorption and pbpk modeling. Recent trends of fast dissolving tablet an overview of formulation technology. Physiologically based pharmacokinetic modeling and. Sjogren et al 2016 40% of anatomical cylindrical volume gisim sjogren et al 2016 0 20 40 60 80 100 120 140 160. The highest values for cv are reported for loq where 20 % deviation is permitted. Gastrointestinal disease lectureppt linkedin slideshare. Application of a dynamic fluid and ph model to simulate. Gastroplus is a mechanistically based simulation software package that simulates intravenous, oral, oral cavity, ocular, inhalation, dermal, subcutaneous, and intramuscular absorption, biopharmaceutics, pharmacokinetics, and pharmacodynamics in humans and animals.
Many downloads like gastroplus may also include a crack, serial number, unlock code, cd key or keygen key generator. Expectations from pkpd modelling and simulation in the. Digestion mechanical physical chew, tear, grind, mash, and mix chemical enzymatic reactions to improve digestion of carbohydrates, proteins, and lipids. Ppt diabetic gastroparesis powerpoint presentation free. This medical powerpoint template designed in dark blue and white colors showing roentgenograms of the internal will be a good help in presentations on rontgenography, problems with intestine or stomach, stomach ulcer, gastroenterology, etc.
Plasma concentrations and f% are typically predicted within 10 fold for. Clinical biochemistry gastrointestinal disease in the name of god 2. Once a feature is discussed, trainees then use it on their. Differential equations oral absorption and related phenomena release, dissolution, precipitation transit absorption passive diffusion and carriermediated transport pharmacokinetics gut and liver metabolism. Click create pdf xps document, then click create pdf xps. It includes the esophagus, stomach, small intestine, large intestine, colon, rectum, biliary tract, gallbladder, liver, and pancreas. Gastroplus model 150 mg solution dose pbbm model describes solution dose well in terms of cmax and tmaxpredicting 60% drug metabolized in gut vs. All pbpk simulations were carried out using the commercially available software gastroplus tm version 8. Pbpk modeling software from discovery through development.
General workflow of pbpk model development and validation criterion. The oral absorption module is based on an absorption model called advanced compartmental and transit model agoram et al. Translating the effect of product manufacturing variants. Liver, gall bladder, and pancreas liver directly affects digestion by producing bile bile helps digest fat filters out toxins and waste. Evaluation of the gastroplus advanced compartmental and.
Experimentally determined phsolubility profile was used for all simulations. Simple peff and meylan sw 84% within 25% of observed y 1. Physiologically based pharmacokinetic modeling and simulation. In the publish as pdf or xps dialog box, choose a location to save the file to. We put together an initial overview as a list of products available for download and commenting. Prediction of pharmacokinetics and drugdrug interaction.
Human pharmacokinetics profiles of indomethacin in nonpregnant and pregnant. Scheer4 1drug product science and technology, bristolmyers squibb, new brunswick, new jersey 08901 2drug product science and technology. A range of experimentally determined, in silico predicted or literature data were used as input parameters. Eosinophilic gastrointestinal diseases icd9 coordination committee meeting baltimore, md september 28. The aim of this study was to evaluate the oral exposure predictions obtained early in drug discovery with a generic gastroplus advanced compartmental and transit acat model based on the in vivo intravenous blood concentrationtime profile, in silico properties lipophilicity, pka and in vitro highthroughput absorptiondistributionmetabolismexcretion adme data as determined by pampa. Concentration is calculated as c a v 1 where a is amount of drug and v is the volume of distribution. A quick trip through the gi track with brief stops at the esophagus, stomach, liver, colon, rectum and anus. October 26 27, 2017 in mumbai, india simulations plus. The program has three input tabs, namely compound, physiology, and pharmacokinetics, comprising three sets of factors influencing oral drug absorption. Development of physiologically based pharmacokinetic. However, there remains a lack of comparative studies between different models.
The aim of this study was to explore the strengths and limitations of the in silico absorption models simcyp. The slide decks were realized with support of eli lilly. In silico modeling of gastrointestinal drug absorption. Gastroplus will allow for optimum implementation of animal alternatives in novel high throughput safety assessment programs tox21 title. A lecture in powerpoint format for a human anatomy unit covering the digestive system. Welcome to s free digestive system powerpoint templates section. In vitro adme cyp, ppb, lm, sol early assessment of in vitro adme in vivo activity rat mes screen 10mgkg w plasmabrain levels and estimate of metabolites kcnq23, herg ep and early in vivo pk electrophysiology pk profile rat ivpo mes and lma ed 50 therapeutic index definitive in vivo pk drugdrug interactions pain ed 50. To facilitate a priori predictions of oral absorption, most commercially available modeling platforms i. Gastrulation rearranges the blastula to form a threelayered embryo with a primitive gut gastrulation rearranges the embryo into a triploblastic gastrula. In vitro to in vivo extrapolation for high throughput prioritization and decision making article pdf available in toxicology in vitro 47 december 2017 with 556 reads how we measure reads. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Nov 19, 2014 to facilitate a priori predictions of oral absorption, most commercially available modeling platforms i.
Save powerpoint presentations as pdf files office support. When you save presentation as a pdf file it freezes the formatting and layout. Pbpk modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals. Physiologically based pharmacokinetic pbpk modeling and. In this work, a dynamic fluid and ph model was applied in gastroplus to simulate intraluminal and systemic. Gupta a, mishra a, gupta v, bansal p, singh r and singh a. In early phases, pharmaceutical profiling can help to find an appropriate druglike molecule for preclinical and clinical development, and in later stages, extended biopharmaceutical evaluation can be used to guide formulation strategy or to predict the. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Translating the effect of product manufacturing variants from in vitro to the clinic. Digestive system powerpoint lecture digestion human.
Computer simulation in pharmacokinetic and pharmacodynamic. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Clinical biochemistry gastrointestinal disease gastrointestinal disease peptic ulcer disease chronic duodenal ulcer chronic benign gastric ulcer zollinger. The underlying model in gastroplus is the acat model agoram et al. Gastroplus is advanced software to simulate oral absorption, pks, and pds in animals and humans based on molecular, physical, biopharmaceutical, and pharmacological attributes of a drug. Mechanistic deconvolution and the future role of physiological modeling in ivivc michael b. The compartment of the fetoplacental units was also assumed to be perfusion rate limited. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. The gastrointestinal gi tract is composed of organs and tissues that have diverse forms and functions. The oral absorption module is based on an absorption model called advanced compartmental and transit model.
In vitroin vivo correlation for gliclazide immediate. We are pleased to present the highlights and key findings in digestive cancers from esmo 2019 congress. Gastroplus pbpk and admet predictor qsar modeling to prioritize testing of chemicals for the tox21 program presented work at past two society of toxicology sot meetings first publications expected in 2016 14. All specialties including cardiology, dermatology, ophthalmology, dentistry, hepatology, nephrology, neurology powerpoints and templates are free for download. Validation of thevalidation of the gastroplustm software. Gastrointestinal gi drug absorption is a complex process determined by formulation, physicochemical and biopharmaceutical factors, and gi physiology. Simplifying your search should return more download results. Pbpk modeling is used in pharmaceutical research and drug development, and in health risk. Mechanistic modeling and simulation of oral drug absorption. In a buffered solution a dianion salt is formed due to which its solubility is. There is a wide range of excipients for direct compression with different functions available in the market.
Target adult exposure on standard doses homogeneous exposure across and within cohorts is the typical goal define target which exposure metrics, at what time, from what source trial. Biopharmaceutical assessment of drugs is of crucial importance in different phases of drug discovery and development. People can view the slides even if they dont have powerpoint, but they cant make changes to it. Pdf in vitro to in vivo extrapolation for high throughput. This section of the website hosts free digestive system powerpoint templates and free stomach powerpoint templates specially designed for doctors, academicians, students and other professionals, who often need to create powerpoint presentations on digestive. Gastroplus advanced compartmental absorption transit mechanistic absorption model. As much as possible, the training uses powerpoint slides to introduce software features. Gastroplus is a mechanistically based simulation software package that simulates. Primary germ layers ectoderm endoderm mesoderm gastrulation is the first stage in forming the body plan. Current possibilities and gaps for immediate release formulations jim mullin, team leader simulation technologies.
Gastroplus software training is best done in an environment where each person operates the program and takes an active part in running simulations along with the instructor. The aim of this study was to develop a drugspecific absorption model for gliclazide glk using mechanistic gastrointestinal simulation technology gist implemented in gastroplus tm software package. The reason is that concentration of a drug is relatively easy to measure from a blood sample and at the same time concentration is a key factor when modelling both positive and negative e ects of a drug. Physiologically based pharmacokinetic pbpk modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion adme of synthetic or natural chemical substances in humans and other animal species. Gastroenterology swedish family practice residency didactics july 31, 2001 2. Gastroplus pbpk methodology if the provided physicochemical and biopharmaceutical properties are correct. However, it is possible that many users are not completely familiar with, or aware of, the assumptions made and. Request pdf a framework for 2stage global sensitivity analysis of gastroplus compartmental models parameter sensitivity and. Jun 26, 2012 gastrointestinal disease lectureppt 1.
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